late 15c., "intertwined, past-participle adjective from twist (v.). Meaning "perverted, mentally strange" (1900) probably is from twist (n.) in a sense of "mental peculiarity, perversion" attested by 1811.
Entries linking to twisted
twist v.
c. 1200 (implied in past tense form twaste), "to wring," from twist (n.). Sense of "to spin two or more strands of yarn into thread" is attested from late 15c. Meaning "to move in a winding fashion" is recorded from 1630s. To twist the lion's tail was U.S. slang (1895) for "to provoke British feeling" (the lion being the symbol of Britain). To twist (someone's) arm in the figurative sense of "pressure (to do something)" is from 1945. Related: Twisted; twisting.