stir-crazy adj.

1570s, "diseased, sickly" (a sense now obsolete); 1580s, "broken, impaired, full of cracks or flaws," from craze + -y (2). Meaning "deranged, demented, of unsound mind or behaving as so" is from 1610s. Jazz slang sense "cool, exciting" is attested by 1927. Related: Crazily; craziness.

To drive (someone) crazy is attested by 1873. To do something like crazy "with manic vigor or frequency" is by 1905. Phrase crazy like a fox has origins by 1935. Crazy Horse, name of the Teton Lakhota (Siouan) war leader (d. 1877), translates thašuka witko, literally "his horse is crazy." Crazy-quilt (1886) preserves the original "break to pieces" sense of craze (v.). Crazy bone as an alternative to funny bone is recorded by 1853.

"commotion, disturbance, tumult," late 14c. (in phrase on steir), probably from a Scandinavian source, such as Old Norse styrr "disturbance, tumult," from the same root as stir (v.)). The sense of "movement, bustle" (1560s) probably is from the English verb.