"a tumor resembling a nipple," 1866, a modern Latin hybrid from papilla "nipple" + -oma "tumor," which is from Greek.
Entries linking to papilloma
papilla n.
plural papillae, 1690s, "a nipple of a mammary gland," from Latin papilla "nipple," diminutive of papula "swelling" (see pap (n.2)). Meaning "nipple-like protuberance" attested from 1713.
-oma
word-forming element, from Greek -oma, with -o-, lengthened stem vowel + -ma, suffix forming neuter nouns and nouns that indicate result of verbal action (equivalent of Latin -men); especially taken in medical use as "morbid growth, tumor," based on sarcoma, carcinoma.