"bitter fluid secreted by the liver of an ox, used in paints and coloring," 1630s, from ox + gall (n.1).
Entries linking to ox-gall
ox n.
"the domestic Bos taurus" (commonly meaning the castrated males, used to pull loads or for food), Middle English oxe, from Old English oxa "ox" (plural oxan), from Proto-Germanic *ukhson (source also of Old Norse oxi, Old Frisian oxa, Middle Dutch osse, Old Saxon, Old High German ohso, German Ochse, Gothic auhsa), from PIE *uks-en- "male animal," (source also of Welsh ych "ox," Middle Irish oss "stag," Sanskrit uksa, Avestan uxshan- "ox, bull"), said to be from root *uks- "to sprinkle," related to *ugw- "wet, moist." The animal word, then, is literally "besprinkler."
Also used from late Old English of the wild, undomesticated bovines. The black ox "misfortune, adversity, old age," etc., is by 1540s.
gall n.1
"bile, liver secretion," Old English galla (Anglian), gealla (West Saxon) "gall, bile," from Proto-Germanic *gallon "bile" (source also of Old Norse gall "gall, bile; sour drink," Old Saxon galle, Old High German galla, German Galle), from PIE root *ghel- (2) "to shine," with derivatives denoting "green, yellow," and thus "bile, gall." Informal sense of "impudence, boldness" first recorded American English 1882; but meaning "embittered spirit, rancor" is from c. 1200, from the old medicine theory of humors.