maladaptation n.

word-forming element of Latin origin meaning "bad, badly, ill, poorly, wrong, wrongly," from French mal (adv.), from Old French mal (adj., adv.) "evil, ill, wrong, wrongly" (9c.), from Latin male (adv.) "badly," or malus (adj.) "bad, evil" (fem. mala, neuter malum), from Proto-Italic *malo-, from PIE *mol-o-, probably from PIE root *mel- (3) "false, bad, wrong."

Most Modern English words with this element are 19c. coinages. It generally implies imperfection or deficiency, but often it is simply negative (as in malfeasance, malcontent). It is equivalent to dys- and caco- of Greek origin and Germanic mis- (1).

c. 1600, "action of adapting (something to something else)," from French adaptation, from Late Latin adaptationem (nominative adaptatio), noun of action from past-participle stem of adaptare "to adjust," from ad "to" (see ad-) + aptare "to join," from aptus "fitted" (see apt).

The meaning "condition of being adapted, state of being fitted to circumstances or relations" is from 1670s. The sense of "modification of a thing to suit new conditions" is from 1790. The biological sense of "variations in a living thing to suit changed conditions" is by 1859, in Darwin's writings.