LSD

in reference to a crystalline organic compound, 1934, from the -lys- in hydrolysis (thus from Greek lysis "a loosening, a dissolution," from lyein "to loosen, dissolve;" from PIE root *leu- "to loosen, divide, cut apart") + the first syllable of ergot (a fungus from which the chemical was first obtained) + -ic.

Old English sur "sharp and acidic to the taste, tart, acid, fermented," from Proto-Germanic *sura- "sour" (source also of Old Norse surr, Middle Dutch suur, Dutch zuur, Old High German sur, German sauer), from PIE root *suro- "sour, salty, bitter" (source also of Old Church Slavonic syru, Russian syroi "moist, raw;" Lithuanian sūras "salty," sūris "cheese").

The meaning "harsh of temper, crabbed, having a peevish disposition" is from early 13c. The sense in whisky sour (1885) is "with lemon added" (1862). Sour cream is attested from 1855. French sur "sour, tart" (12c.) is a Germanic loan-word.

1690s, from acid (adj.); originally loosely applied to any substance having a sour taste like vinegar, in modern chemistry it was gradually given more precise definitions from early 18c. and is given to many compounds which do not have such a taste.

The slang meaning "LSD-25" first recorded 1966 (see LSD).

When I was on acid I would see things that looked like beams of light, and I would hear things that sounded an awful lot like car horns. [Mitch Hedberg, 1968-2005, U.S. stand-up comic]

Acid rock (type performed or received by people using LSD) is also from 1966; acid house dance music style is 1988, probably from acid in the hallucinogenic sense + house "dance club DJ music style."