1762, coined by Ben Franklin as the name for a glass harmonica, from Latin fem. of harmonicus (see harmonic); modern sense of "reeded mouth organ" is 1873, American English, earlier harmonicon (1825).
Entries linking to harmonica
harmonic adj.
1560s, "relating to music," from Latin harmonicus, from Greek harmonikos "harmonic, musical, skilled in music," from harmonia (see harmony). From 1660s as "tuneful, harmonious; relating to harmony" (earlier as armonical "tuneful, harmonious," c. 1500). The noun, short for harmonic tone, is recorded from 1777. Related: Harmonically.