exacerbation n.

word-forming element, in English meaning usually "out of, from," but also "upwards, completely, deprive of, without," and "former;" from Latin ex "out of, from within; from which time, since; according to; in regard to," from PIE *eghs "out" (source also of Gaulish ex-, Old Irish ess-, Old Church Slavonic izu, Russian iz). In some cases also from Greek cognate ex, ek. PIE *eghs had comparative form *eks-tero and superlative *eks-t(e)r-emo-. Often reduced to e- before -b-, -d-, -g-, consonantal -i-, -l-, -m-, -n-, -v- (as in elude, emerge, evaporate, etc.).

Proto-Indo-European root meaning "be sharp, rise (out) to a point, pierce."

It forms all or part of: acacia; acanthus; accipiter; acer; acerbic; acerbity; acervate; acervulus; acescent; acetic; acid; acicular; acme; acne; acrid; acridity; acrimony; acro-; acrobat; acromegaly; acronym; acrophobia; acropolis; acrostic; acrylic; acuity; aculeate; acumen; acupressure; acupuncture; acute; aglet; ague; Akron; anoxic; awn; coelacanth; dioxin; deoxy-; eager; ear (n.2) "grain part of corn;" edge (n.); egg (v.) "to goad on, incite;" eglantine; epoxy; ester; exacerbation; hammer; hypoxia; mediocre; oxalic; oxide; oxy-; oxygen; oxymoron; paragon; pyracanth; paroxysm; selvage; vinegar.

It is the hypothetical source of/evidence for its existence is provided by: Greek akros "at the end, at the top, outermost; consummate, excellent," akis "sharp point," akē "point of an iron tool," akantha "thorn," akmē "summit, edge," oxys "sharp, bitter;" Sanskrit acri- "corner, edge," acani- "point of an arrow," asrih "edge;" Oscan akrid (ablative singular) "sharply;" Latin acer (fem. acris) "sharp to the senses, pungent, bitter, eager, fierce," acutus "sharp, pointed," acuere "to sharpen," acerbus "harsh, bitter," acere "be sharp, be bitter," acus "a needle, pin," ocris "jagged mountain;" Lithuanian ašmuo "sharpness," akstis "sharp stick;" Old Lithuanian aštras, Lithuanian aštrus "sharp;" Old Church Slavonic ostru, Russian óstryj "sharp;" Old Irish er "high;" Welsh ochr "edge, corner, border;" Old Norse eggja "goad;" Old English ecg "sword;" German Eck "corner."

"increase the bitterness or virulence of, make (a feeling, a conflict, etc.) more hostile or malignant," 1650s, a back-formation from exacerbation or else from Latin exacerbatus, past participle of exacerbare "irritate, provoke." Related: Exacerbated; exacerbating.