1873, "situated on or affecting the dura mater," from epi- "on" + dura mater + -al (1). The noun meaning "injection into the epidural region" (usually given during childbirth) is attested by 1966.
Entries linking to epidural
epi-
before vowels reduced to ep-, before aspirated vowels eph-, word-forming element meaning "on, upon, above," also "in addition to; toward, among," from Greek epi "upon, at, close upon (in space or time), on the occasion of, in addition," also "after," from PIE *epi, *opi "near, at, against" (source also of Sanskrit api "also, besides;" Avestan aipi "also, to, toward;" Armenian ev "also, and;" Latin ob "toward, against, in the way of;" Oscan op, Greek opi- "behind;" Hittite appizzis "younger;" Lithuanian ap- "about, near;" Old Church Slavonic ob "on"). A productive prefix in Greek; also used in modern scientific compounds (such as epicenter).
dura mater n.
"tough outer membrane surrounding the brain and the spinal cord," c. 1400, from Medieval Latin dura mater cerebri, literally "hard mother of the brain," a loan-translation of Arabic umm al-dimagh as-safiqa, literally "thick mother of the brain." "In Arabic, the words 'father,' 'mother,' and 'son' are often used to denote relationships between things" [Klein].
-al 1
suffix forming adjectives from nouns or other adjectives, "of, like, related to, pertaining to," Middle English -al, -el, from French or directly from Latin -alis (see -al (2)).