disease n.

word-forming element of Latin origin meaning 1. "lack of, not" (as in dishonest); 2. "opposite of, do the opposite of" (as in disallow); 3. "apart, away" (as in discard), from Old French des- or directly from Latin dis- "apart, asunder, in a different direction, between," figuratively "not, un-," also "exceedingly, utterly." Assimilated as dif- before -f- and to di- before most voiced consonants.

The Latin prefix is from PIE *dis- "apart, asunder" (source also of Old English te-, Old Saxon ti-, Old High German ze-, German zer-). The PIE root is a secondary form of *dwis- and thus is related to Latin bis "twice" (originally *dvis) and to duo, on notion of "two ways, in twain" (hence "apart, asunder").

In classical Latin, dis- paralleled de- and had much the same meaning, but in Late Latin dis- came to be the favored form and this passed into Old French as des-, the form used for compound words formed in Old French, where it increasingly had a privative sense ("not"). In English, many of these words eventually were altered back to dis-, while in French many have been altered back to de-. The usual confusion prevails.

As a living prefix in English, it reverses or negatives what it is affixed to. Sometimes, as in Italian, it is reduced to s- (as in spend, splay, sport, sdain for disdain, and the surnames Spencer and Spence).

c. 1200, "physical comfort, undisturbed state of the body; tranquility, peace of mind," from Old French aise "comfort, pleasure, well-being; opportunity," which is of uncertain origin. According to Watkins is ultimately from Latin adiacens "lying at," present participle of adiacere "lie at, border upon, lie near," from ad "to" (see ad-) + iacere "to lie, rest," literally "to throw" (from PIE root *ye- "to throw, impel"). Recent dictionaries in English and French seem to support this derivation, though older sources found objections to it. Compare adagio.

At ease "at rest, at peace, in comfort" is from late 14c.; as a military order (1802) the word denotes "freedom from stiffness or formality."

"affected with a disease," late 15c., past-participle adjective from disease (v.).