"incapable of being mixed" (as oil and water are), 1670s, from assimilated form of in- "not, opposite of" (see in- (1)) + miscible, from Latin miscere "to mix" (from PIE root *meik- "to mix").
Entries linking to immiscible
in- 1
word-forming element meaning "not, opposite of, without" (also im-, il-, ir- by assimilation of -n- with following consonant, a tendency which began in later Latin), from Latin in- "not," cognate with Greek an-, Old English un-, all from PIE root *ne- "not."
In Old French and Middle English often en-, but most of these forms have not survived in Modern English, and the few that do (enemy, for instance) no longer are felt as negative. The rule of thumb in English has been to use in- with obviously Latin elements, un- with native or nativized ones.
miscible adj.
"capable of being mixed," 1560s, from Medieval Latin miscibilis "mixable," from Latin miscere "to mix" (from PIE root *meik- "to mix"). Related: Miscibility.
*meik-
also *meig-, Proto-Indo-European root meaning "to mix."
It forms all or part of: admix; admixture; immiscible; mash; meddle; medley; melange; melee; mestizo; metis; miscegenation; miscellaneous; miscible; mix; mixo-; mixture; mustang; pell-mell; promiscuous.
It is the hypothetical source of/evidence for its existence is provided by: Sanskrit misrah "mixed;" Greek misgein, mignynai "to mix, mix up, mingle; to join, bring together; join (battle); make acquainted with;" Old Church Slavonic mešo, mesiti "to mix," Russian meshat, Lithuanian maišau, maišyti "to mix, mingle," Welsh mysgu "to mix."