1670s, from cross- + breed (v.). As a noun from 1774. Related: Cross-breeding; cross-bred.
Entries linking to cross-breed
cross-
word-forming element typically representing cross as a noun, adverb (cross-examine), adjective (crossbar), and in many words a confluence of them. "There is no distinct line of division between cross as an adjective and cross as a prefix. As a prefix, it often represents the adv. cross, or the prep. cross, across." [Century Dictionary]
breed v.
Old English bredan "bring (young) to birth, procreate," also "cherish, keep warm," from West Germanic *brodjan (source also of Old High German bruoten, German brüten "to brood, hatch"), from *brod- "fetus, hatchling," from PIE root *bhreu- "to boil, bubble, effervesce, burn." The etymological notion is incubation, warming to hatch.
The intransitive sense "come into being" is from c. 1200; that of "beget or bear offspring" is from mid-13c. Of livestock, etc., "procure by the mating of parents and rear for use," mid-14c. The sense of "grow up, be reared" (in a clan, etc.) is late 14c.; the meaning "form by education" is from mid-15c. Related: Bred; breeding.