"nauseated feeling, disordered indisposition in the bowels," 1823, probably a fanciful formation from colic and wobble. Perhaps suggested by cholera morbus.
Entries linking to collywobbles
colic n.
"disease characterized by severe spasmodic abdominal pain," early 15c., from Late Latin colicus "pertaining to colic," from Greek kolikos, belonging to the kolon "lower intestine" (see colon (n.2)). The word was used in English late 14c. as an adjective, "affecting the colon." Related: Colicky (1742).
wobble v.
1650s, wabble, probably from Low German wabbeln "to wobble;" cognate with Old Norse vafla "hover about, totter," related to vafra "move unsteadily," from Proto-Germanic *wab- "to move back and forth," perhaps from PIE *webh- "to weave" (see waver). Form with -o- is from 1851. Related: Wobbled; wobbling. The noun is attested from 1690s.