"suffering complete loss of brain functioning," 1971 (brain death is from 1968), from brain (n.) + dead. Popularized in U.S. 1975 by journalistic coverage of the Karen Anne Quinlan case.
Entries linking to brain-dead
brain n.
"soft, grayish mass filling the cranial cavity of a vertebrate," in the broadest sense, "organ of consciousness and the mind," Old English brægen "brain," from Proto-Germanic *bragnan (source also of Middle Low German bregen, Old Frisian and Dutch brein), a word of uncertain origin, perhaps from PIE root *mregh-m(n)o- "skull, brain" (source also of Greek brekhmos "front part of the skull, top of the head").
But Liberman writes that brain "has no established cognates outside West Germanic" and is not connected to the Greek word. More probably, he writes, its etymon is PIE *bhragno "something broken."
The custom of using the plural to refer to the substance (literal or figurative), as opposed to the organ, dates from 16c. The figurative sense of "intellectual power" is from late 14c.; the meaning "a clever person" is recorded by 1914.
To have something on the brain "be extremely eager for or interested in" is from 1862. Brain-fart "sudden loss of memory or train of thought; sudden inability to think logically" is by 1991 (brain-squirt is from 1650s as "feeble or abortive attempt at reasoning"). An Old English word for "head" was brægnloca, which might be translated as "brain locker." In Middle English, brainsick (Old English brægenseoc) meant "mad, addled."
dead adj.
Middle English ded, from Old English dead "having ceased to live," also "torpid, dull;" of water, "still, standing," from Proto-Germanic *daudaz (source also of Old Saxon dod, Danish død, Swedish död, Old Frisian dad, Middle Dutch doot, Dutch dood, Old High German tot, German tot, Old Norse dauðr, Gothic dauþs "dead"), a past-participle adjective based on *dau-, which is perhaps from PIE *dheu- (3) "to die" (see die (v.)).
Meaning "insensible, void of perception" is from early 13c. Of places, "inactive, dull," from 1580s. Of sound, "muffled," 1520s. Used from 16c. as "utter, absolute, quite" (as in dead drunk, 1590s); from 1590s as "quite certain, sure, unerring;" by 1881 as "direct, straight." Dead heat, a race in which more than one competitor reaches the goal at the same time, is from 1796. The dead-nettle (c. 1400) resembles the nettle but does not sting.
Dead on is 1889, from marksmanship. Dead duck "person defeated or soon to be, useless person" is by 1844, originally in U.S. politics. Dead letter is from 1703, used of laws lacking force as well as uncollected mail. Dead soldier "emptied liquor bottle" is from 1913; the image is older (compare dead men "bottles emptied at a banquet," c. 1700). Dead man's hand in poker, "pair of aces and pair of eights," is supposedly what Wild Bill Hickock held when Jack McCall shot him in 1876. Expression not be (seen/found/caught) dead "have nothing to do with" is by 1915.