atomize v.

late 15c., as a hypothetical indivisible extremely minute body, the building block of the universe, from Latin atomus (especially in Lucretius) "indivisible particle," from Greek atomos "uncut, unhewn; indivisible," from a- "not" (see a- (3)) + tomos "a cutting," from temnein "to cut" (from PIE root *tem- "to cut").

An ancient term of philosophical speculation (in Leucippus, Democritus); revived scientifically 1805 by British chemist John Dalton. In late classical and medieval use also a unit of time, 22,560 to the hour. Atom bomb is from 1945 as both a noun and a verb; compare atomic.

word-forming element used to make verbs, Middle English -isen, from Old French -iser/-izer, from Late Latin -izare, from Greek -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached.

The variation of -ize and -ise began in Old French and Middle English, perhaps aided by a few words (such as surprise, see below) where the ending is French or Latin, not Greek. With the classical revival, English partially reverted to the correct Greek -z- spelling from late 16c. But the 1694 edition of the authoritative French Academy dictionary standardized the spellings as -s-, which influenced English.

In Britain, despite the opposition to it (at least formerly) of OED, Encyclopaedia Britannica, the Times of London, and Fowler, -ise remains dominant. Fowler thinks this is to avoid the difficulty of remembering the short list of common words not from Greek which must be spelled with an -s- (such as advertise, devise, surprise). American English has always favored -ize. The spelling variation involves about 200 English verbs.