uptake n.

Old English up, uppe, from Proto-Germanic *upp- "up" (source also of Old Frisian, Old Saxon up "up, upward," Old Norse upp; Danish, Dutch op; Old High German uf, German auf "up"; Gothic iup "up, upward," uf "on, upon, under;" Old High German oba, German ob "over, above, on, upon"), from PIE root *upo "under," also "up from under," hence also "over."

As a preposition, "to a higher place" from c. 1500; also "along, through" (1510s), "toward" (1590s). Often used elliptically for go up, come up, rise up, etc. Up the river "in jail" first recorded 1891, originally in reference to Sing Sing, which is up the Hudson from New York City. To drive someone up the wall (1951) is from the notion of the behavior of lunatics or caged animals. Insulting retort up yours (scil. ass) is attested by late 19c.

late Old English tacan "to take, seize," from a Scandinavian source (such as Old Norse taka "take, grasp, lay hold," past tense tok, past participle tekinn; Swedish ta, past participle tagit), from Proto-Germanic *takan- (source also of Middle Low German tacken, Middle Dutch taken, Gothic tekan "to touch"), from Germanic root *tak- "to take," of uncertain origin, perhaps originally meaning "to touch."

As the principal verb for "to take," it gradually replaced Middle English nimen, from Old English niman, from the usual West Germanic verb, *nemanan (source of German nehmen, Dutch nemen; see nimble).

OED calls take "one of the elemental words of the language;" take up alone has 55 varieties of meaning in that dictionary's 2nd print edition. Basic sense is "to lay hold of," which evolved to "accept, receive" (as in take my advice) c. 1200; "absorb" (take a punch) c. 1200; "choose, select" (take the high road) late 13c.; "to make, obtain" (take a shower) late 14c.; "to become affected by" (take sick) c. 1300.

Take five is 1929, from the approximate time it takes to smoke a cigarette. Take it easy is recorded by 1880; take the plunge "act decisively" is from 1876; take the rap "accept (undeserved) punishment" is from 1930. Phrase take it or leave it is recorded from 1897. To take (something) on "begin to do" is from late 12c. To take it out on (someone or something) "vent one's anger on other than what caused it" is by 1840.

also re-uptake, by 1977; see re- + uptake (n.).