antagonise v.

1630s, "to compete with" (obsolete); 1742, "act in opposition to, struggle against continuously," from Greek antagonizesthai "to struggle against, oppose, be a rival," from anti "against" (see anti-) + agonizesthai "to contend for a prize," from agon "a struggle, a contest" (see agony). The meaning "make antagonistic" is by 1882. Related: Antagonized; antagonizing; antagonization.

word-forming element used to make verbs, Middle English -isen, from Old French -iser/-izer, from Late Latin -izare, from Greek -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached.

The variation of -ize and -ise began in Old French and Middle English, perhaps aided by a few words (such as surprise, see below) where the ending is French or Latin, not Greek. With the classical revival, English partially reverted to the correct Greek -z- spelling from late 16c. But the 1694 edition of the authoritative French Academy dictionary standardized the spellings as -s-, which influenced English.

In Britain, despite the opposition to it (at least formerly) of OED, Encyclopaedia Britannica, the Times of London, and Fowler, -ise remains dominant. Fowler thinks this is to avoid the difficulty of remembering the short list of common words not from Greek which must be spelled with an -s- (such as advertise, devise, surprise). American English has always favored -ize. The spelling variation involves about 200 English verbs.