amyotrophic lateral sclerosis n.

prefix meaning "not, without," from Greek a-, an- "not" (the "alpha privative"), from PIE root *ne- "not" (source also of English un-).

In words from Greek, such as abysmal, adamant, amethyst; also partly nativized as a prefix of negation (asexual, amoral, agnostic). The ancient alpha privatum, denoting want or absence.

Greek also had an alpha copulativum, a- or ha-, expressing union or likeness, which is the a- expressing "together" in acolyte, acoustic, Adelphi, etc. It is from PIE root *sem- (1) "one; as one, together with."

"contractible animal tissue consisting of bundles of fibers," late 14c., "a muscle of the body," from Latin musculus "a muscle," literally "a little mouse," diminutive of mus "mouse" (see mouse (n.)).

So called because the shape and movement of some muscles (notably biceps) were thought to resemble mice. The analogy was made in Greek, too, where mys is both "mouse" and "muscle," and its combining form gives the medical prefix myo-. Compare also Old Church Slavonic mysi "mouse," mysica "arm;" German Maus "mouse; muscle," Arabic 'adalah "muscle," 'adal "field mouse;" Cornish logodenfer "calf of the leg," literally "mouse of the leg." In Middle English, lacerte, from the Latin word for "lizard," also was used as a word for a muscle.

Musclez & lacertez bene one selfe þing, Bot þe muscle is said to þe fourme of mouse & lacert to þe fourme of a lizard. [Guy de Chauliac, "Grande Chirurgie," c. 1425]

Hence muscular and mousy are relatives, and a Middle English word for "muscular" was lacertous, "lizardy." Figurative sense of "muscle, strength, brawn" is by 1850; that of "force, violence, threat of violence" is 1930, American English. Muscle car "hot rod" is from 1969.

word-forming element meaning "food, nourishment," from Greek -trophia, from trophe "food, nourishment," related to trephein "make thrive, nourish, rear; to make solid, congeal, thicken."