1520s, from un- (1) "not" + past participle of acquaint (v.).
Entries linking to unacquainted
un- 1
prefix of negation, Old English un-, from Proto-Germanic *un- (source also of Old Saxon, Old Frisian, Old High German, German un-, Gothic un-, Dutch on-), from PIE *n- (source of Sanskrit a-, an- "not," Greek a-, an-, Old Irish an-, Latin in-), combining form of PIE root *ne- "not." Often euphemistic (such as untruth for "lie").
The most prolific of English prefixes, freely and widely used in Old English, where it forms more than 1,000 compounds. It underwent a mass extinction in early Middle English, but emerged with renewed vigor 16c. to form compounds with native and imported words. It disputes with Latin-derived cognate in- (1) the right to form the negation of certain words (indigestable/undigestable, etc.), and though both might be deployed in cooperation to indicate shades of meaning (unfamous/infamous), typically they are not.
It also makes words from phrases (such as uncalled-for, c. 1600; undreamed-of, 1630s; uncome-at-able, 1690s; unputdownable, 1947, of a book; un-in-one-breath-utterable, Ben Jonson; etc., but the habit is not restricted to un-; such as put-up-able-with, 1812). As a prefix in telegramese to replace not and save the cost of a word, it is attested by 1936.
acquaint v.
early 13c., "make oneself known" (reflexive, now obsolete); early 14c., "to gain for oneself personal knowledge of," from Old French acointer "make known; make or seek acquaintance of," from Vulgar Latin *accognitare "to make known," from Latin accognitus "acquainted with," past participle of accognoscere "know well," from ad "to" (see ad-) + cognitus, past participle of cognoscere "come to know" (see cognizance).
Meaning "to inform (someone of something), furnish with knowledge or information" is from 1550s. Related: Acquainted; acquainting.