systemic adj.

1610s, "the whole creation, the universe," from Late Latin systema "an arrangement, system," from Greek systema "organized whole, a whole compounded of parts," from stem of synistanai "to place together, organize, form in order," from syn- "together" (see syn-) + root of histanai "cause to stand," from PIE root *sta- "to stand, make or be firm."

Meaning "set of correlated principles, facts, ideas, etc." first recorded 1630s. Meaning "animal body as an organized whole, sum of the vital processes in an organism" is recorded from 1680s; hence figurative phrase to get (something) out of one's system (1900). Computer sense of "group of related programs" is recorded from 1963. All systems go (1962) is from U.S. space program. The system "prevailing social order" is from 1806.

Middle English -ik, -ick, word-forming element making adjectives, "having to do with, having the nature of, being, made of, caused by, similar to," from French -ique and directly from Latin -icus or from cognate Greek -ikos "in the manner of; pertaining to." From PIE adjective suffix *-(i)ko, which also yielded Slavic -isku, adjectival suffix indicating origin, the source of the -sky (Russian -skii) in many surnames. In chemistry, indicating a higher valence than names in -ous (first in benzoic, 1791).

In Middle English and after often spelled -ick, -ike, -ique. Variant forms in -ick (critick, ethick) were common in early Modern English and survived in English dictionaries into early 19c. This spelling was supported by Johnson but opposed by Webster, who prevailed.