systematize v.

1610s, "the whole creation, the universe," from Late Latin systema "an arrangement, system," from Greek systema "organized whole, a whole compounded of parts," from stem of synistanai "to place together, organize, form in order," from syn- "together" (see syn-) + root of histanai "cause to stand," from PIE root *sta- "to stand, make or be firm."

Meaning "set of correlated principles, facts, ideas, etc." first recorded 1630s. Meaning "animal body as an organized whole, sum of the vital processes in an organism" is recorded from 1680s; hence figurative phrase to get (something) out of one's system (1900). Computer sense of "group of related programs" is recorded from 1963. All systems go (1962) is from U.S. space program. The system "prevailing social order" is from 1806.

word-forming element used to make verbs, Middle English -isen, from Old French -iser/-izer, from Late Latin -izare, from Greek -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached.

The variation of -ize and -ise began in Old French and Middle English, perhaps aided by a few words (such as surprise, see below) where the ending is French or Latin, not Greek. With the classical revival, English partially reverted to the correct Greek -z- spelling from late 16c. But the 1694 edition of the authoritative French Academy dictionary standardized the spellings as -s-, which influenced English.

In Britain, despite the opposition to it (at least formerly) of OED, Encyclopaedia Britannica, the Times of London, and Fowler, -ise remains dominant. Fowler thinks this is to avoid the difficulty of remembering the short list of common words not from Greek which must be spelled with an -s- (such as advertise, devise, surprise). American English has always favored -ize. The spelling variation involves about 200 English verbs.