synthesize v.

1610s, "deductive reasoning," from Latin synthesis "collection, set, suit of clothes, composition (of a medication)," from Greek synthesis "composition, a putting together," from syntithenai "put together, combine," from syn- "together" (see syn-) + tithenai "to put, to place," from reduplicated form of PIE root *dhe- "to set, put." From 1733 as "a combination of parts into a whole." Earlier borrowed in Middle English as sintecis (mid-15c.). Plural syntheses.

word-forming element used to make verbs, Middle English -isen, from Old French -iser/-izer, from Late Latin -izare, from Greek -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached.

The variation of -ize and -ise began in Old French and Middle English, perhaps aided by a few words (such as surprise, see below) where the ending is French or Latin, not Greek. With the classical revival, English partially reverted to the correct Greek -z- spelling from late 16c. But the 1694 edition of the authoritative French Academy dictionary standardized the spellings as -s-, which influenced English.

In Britain, despite the opposition to it (at least formerly) of OED, Encyclopaedia Britannica, the Times of London, and Fowler, -ise remains dominant. Fowler thinks this is to avoid the difficulty of remembering the short list of common words not from Greek which must be spelled with an -s- (such as advertise, devise, surprise). American English has always favored -ize. The spelling variation involves about 200 English verbs.