substance n.

word-forming element meaning "under, beneath; behind; from under; resulting from further division," from Latin preposition sub "under, below, beneath, at the foot of," also "close to, up to, towards;" of time, "within, during;" figuratively "subject to, in the power of;" also "a little, somewhat" (as in sub-horridus "somewhat rough"), from PIE *(s)up- (perhaps representing *ex-upo-), a variant form of the root *upo "under," also "up from under." The Latin word also was used as a prefix and in various combinations.

In Latin assimilated to following -c-, -f-, -g-, -p-, and often -r- and -m-. In Old French the prefix appears in the full Latin form only "in learned adoptions of old Latin compounds" [OED], and in popular use it was represented by sous-, sou-; as in French souvenir from Latin subvenire, souscrire (Old French souzescrire) from subscribere, etc.

The original meaning is now obscured in many words from Latin (suggest, suspect, subject, etc.). The prefix is active in Modern English, sometimes meaning "subordinate" (as in subcontractor); "inferior" (17c., as in subhuman); "smaller" (18c.); "a part or division of" (c. 1800, as in subcontinent).

*stā-, Proto-Indo-European root meaning "to stand, set down, make or be firm," with derivatives meaning "place or thing that is standing."

It forms all or part of: Afghanistan; Anastasia; apostasy; apostate; armistice; arrest; assist; astatic; astatine; Baluchistan; bedstead; circumstance; consist; constable; constant; constitute; contrast; cost; desist; destination; destine; destitute; diastase; distance; distant; ecstasy; epistasis; epistemology; establish; estaminet; estate; etagere; existence; extant; Hindustan; histidine; histo-; histogram; histology; histone; hypostasis; insist; instant; instauration; institute; interstice; isostasy; isostatic; Kazakhstan; metastasis; obstacle; obstetric; obstinate; oust; Pakistan; peristyle; persist; post (n.1) "timber set upright;" press (v.2) "force into service;" presto; prostate; prostitute; resist; rest (v.2) "to be left, remain;" restitution; restive; restore; shtetl; solstice; stable (adj.) "secure against falling;" stable (n.) "building for domestic animals;" stage; stalag; stalwart; stamen; -stan; stance; stanchion; stand; standard; stanza; stapes; starboard; stare decisis; stasis; -stat; stat; state (n.1) "circumstances, conditions;" stater; static; station; statistics; stator; statue; stature; status; statute; staunch; (adj.) "strong, substantial;" stay (v.1) "come to a halt, remain in place;" stay (n.2) "strong rope which supports a ship's mast;" stead; steed; steer (n.) "male beef cattle;" steer (v.) "guide the course of a vehicle;" stem (n.) "trunk of a plant;" stern (n.) "hind part of a ship;" stet; stoa; stoic; stool; store; stound; stow; stud (n.1) "nailhead, knob;" stud (n.2) "horse kept for breeding;" stylite; subsist; substance; substitute; substitution; superstition; system; Taurus; understand.

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit tisthati "stands;" Avestan histaiti "to stand;" Persian -stan "country," literally "where one stands;" Greek histēmi "put, place, cause to stand; weigh," stasis "a standing still," statos "placed," stylos "pillar;" Latin sistere "stand still, stop, make stand, place, produce in court," status "manner, position, condition, attitude," stare "to stand," statio "station, post;" Lithuanian stojuos "I place myself," statau "I place;" Old Church Slavonic staja "place myself," stanu "position;" Gothic standan, Old English standan "to stand," stede "place;" Old Norse steði "anvil;" Old Irish sessam "the act of standing."