secularize v.

c. 1300, seculer, in reference to clergy, "living in the world, not belonging to a religious order," also generally, "belonging to the state" (as opposed to the Church), from Old French seculer, seculare (Modern French séculier) and directly from Late Latin saecularis "worldly, secular, pertaining to a generation or age," in classical Latin "of or belonging to an age, occurring once in an age," from saeculum "age, span of time, lifetime, generation, breed."

This is from Proto-Italic *sai-tlo-, which, according to Watkins, is PIE instrumental element *-tlo- + *sai- "to bind, tie" (see sinew), extended metaphorically to successive human generations as links in the chain of life. De Vaan also connects it with "bind" words and lists as a cognate Welsh hoedl "lifespan, age." An older theory connected it to words for "seed," from PIE root *se- "to sow" (see sow (v.), and compare Gothic mana-seþs "mankind, world," literally "seed of men").

The ancient Roman ludi saeculares was a three-day, day-and-night celebration coming once in an "age" (120 years).  Ecclesiastical writers in Latin used it as those in Greek did aiōn "of this world" (see cosmos). It is the source of French siècle "century." The meaning "of or belonging to an age or a long period," especially occurring once in a century, was in English from 1590s.

From mid-14c. in the general sense of "of or belonging to the world, concerned in earthly more than in spiritual, life;" also of literature, music, etc., "not overtly religious." In English, in reference to humanism and the exclusion of belief in God from matters of ethics and morality, from 1850s. Related: Secularly.

word-forming element used to make verbs, Middle English -isen, from Old French -iser/-izer, from Late Latin -izare, from Greek -izein, a verb-forming element denoting the doing of the noun or adjective to which it is attached.

The variation of -ize and -ise began in Old French and Middle English, perhaps aided by a few words (such as surprise, see below) where the ending is French or Latin, not Greek. With the classical revival, English partially reverted to the correct Greek -z- spelling from late 16c. But the 1694 edition of the authoritative French Academy dictionary standardized the spellings as -s-, which influenced English.

In Britain, despite the opposition to it (at least formerly) of OED, Encyclopaedia Britannica, the Times of London, and Fowler, -ise remains dominant. Fowler thinks this is to avoid the difficulty of remembering the short list of common words not from Greek which must be spelled with an -s- (such as advertise, devise, surprise). American English has always favored -ize. The spelling variation involves about 200 English verbs.

1690s, "conversion to secular purposes," originally in reference to Church property; see secularize + noun ending -ation. General meaning "state of having become secular" is by 1863.