resign v.

word-forming element meaning "back, back from, back to the original place;" also "again, anew, once more," also conveying the notion of "undoing" or "backward," etc. (see sense evolution below), c. 1200, from Old French re- and directly from Latin re- an inseparable prefix meaning "again; back; anew, against."

Watkins (2000) describes this as a Latin combining form conceivably from Indo-European *wret-, metathetical variant of *wert- "to turn." De Vaan says the "only acceptable etymology" for it is a 2004 explanation which reconstructs a root in PIE *ure "back."

In earliest Latin the prefix became red- before vowels and h-, a form preserved in redact, redeem, redolent, redundant, redintegrate, and, in disguise, render (v.). In some English words from French and Italian re- appears as ra- and the  following consonant is often doubled (see rally (v.1)).

The many meanings in the notion of "back" give re- its broad sense-range: "a turning back; opposition; restoration to a former state;" "transition to an opposite state." From the extended senses in "again," re- becomes "repetition of an action," and in this sense it is extremely common as a formative element in English, applicable to any verb. OED writes that it is "impossible to attempt a complete record of all the forms resulting from its use," and adds that "The number of these is practically infinite ...."   

Often merely intensive, and in many of the older borrowings from French and Latin the precise sense of re- is forgotten, lost in secondary senses, or weakened beyond recognition, so that it has no apparent semantic content (receive, recommend, recover, reduce, recreate, refer, religion, remain, request, require). There seem to have been more such words in Middle English than after, e.g. recomfort (v.) "to comfort, console; encourage;" recourse (n.) "a process, way, course." Recover in Middle English also could mean "obtain, win" (happiness, a kingdom, etc.) with no notion of getting something back, also "gain the upper hand, overcome; arrive at;" also consider the legal sense of recovery as "obtain (property) by judgment or legal proceedings." 

And, due to sound changes and accent shifts, re- sometimes entirely loses its identity as a prefix (rebel, relic, remnant, restive, rest (n.2) "remainder," rally (v.1) "bring together"). In a few words it is reduced to r-, as in ransom (a doublet of redemption), rampart, etc.

It was used from Middle English in forming words from Germanic as well as Latin elements (rebuild, refill, reset, rewrite), and was used so even in Old French (regret, regard, reward, etc.).

Prefixed to a word beginning with e, re- is separated by a hyphen, as re-establish, re-estate, re-edify, etc. ; or else the second e has a dieresis over it: as, reëstablish, reëmbark, etc. The hyphen is also sometimes used to bring out emphatically the sense of repetition or iteration : as, sung and re-sung. The dieresis is not used over other vowels than e when re is prefixed : thus, reinforce, reunite, reabolish. [Century Dictionary, 1895]

early 13c., signe, "gesture or motion of the hand," especially one meant to express thought or convey an idea, from Old French signe "sign, mark," from Latin signum "identifying mark, token, indication, symbol; proof; military standard, ensign; a signal, an omen; sign in the heavens, constellation."

According to Watkins, literally "standard that one follows," from PIE *sekw-no-, from root *sekw- (1) "to follow." De Vaan has it from PIE *sekh-no- "cut," from PIE root *sek- "to cut" He writes: "The etymological appurtenance to seco 'to cut' implies a semantic shift of *sek-no- 'what is cut out', 'carved out' > 'sign'." But he also also compares Hebrew sakkin, Aramaic sakkin "slaughtering-knife," and mentions a theory that "both words are probably borrowed from an unknown third source."

It has ousted native token. By c. 1300 as "an indication of some coming event." The meaning "a visible mark or device having some special meaning" is recorded from late 13c.; that of "miraculous manifestation, a miracle demonstrating divine power" is from c. 1300. In reference to one of the 12 divisions of the zodiac, from mid-14c.

The sense of "inscribed board with a characteristic device attached to the front of an inn, shop, etc.," to distinguish it from others is recorded from mid-15c. The meaning "indicator, token or signal of some condition" (late 13c.) is behind sign of the times (1520s). The meaning "conventional mark or symbol in place of words" (in music, mathematics, etc., as in plus sign) is by 1550s. In some uses, the word probably is a shortening of ensign.