"by himself, herself, or itself," 1570s, Latin, literally "by itself;" from per (see per) + se (see se-). The Latin phrase translates Greek kath auto (Aristotle).
Entries linking to per se
per prep.
"through, by means of," 1580s (earlier in various Latin and French phrases, in the latter often par), from Latin per "through, during, by means of, on account of, as in," from PIE root *per- (1) "forward," hence "through, in front of, before, first, chief, toward, near, around, against."
se-
word-forming element in words of Latin origin, "apart, away," from Latin se-, collateral form of sed- "without, apart, aside," probably originally "by one's self, on one's own," and related to sed, Latin reflexive pronoun (accusative and ablative), from PIE *sed-, extended form of root *s(w)e-, pronoun of the third person and reflexive (source also of German sich; see idiom).